Sophia Patsi was born into a musical family in Thessaloniki, Greece. In 2009 she obtained her bachelor's degree in classical singing at the State Conservatory of her hometown, with the highest distinction. She decided to continue her studies abroad and travelled to Germany, where she studied for a year with Cheryl Studer. After that, Sophia moved to the Netherlands, where she followed a dual study programme: historical performance practice with Xenia Meijer and classical singing with Valerie Guillorit.
Sophia is a permanent member of the Chorus of Dutch National Opera and one of the founders of the ensembles Seconda Pratica, Himeros and Broke Konsort. She has also worked with numerous European ensembles and sung as a soloist in operas, oratorios and concerts all over the world - with conductors such as Markellos Chryssicos, Davide Pozzi, Adrián Rodríguez Van der Spoel, Quentin Clare, Matthias Pintscher, Richard Egarr, Andres Locatelli, Alfredo Bernardini, Sigiswald Kuijken, Marcus Creed, Ivo Meinen, Teunis van der Zwart and Menno van Delft.
Sophia recently sang in the role of La Messagiera L'Orfeo with Latinitas Nostra (conductor Markellos Chryssicos) in Athens and with La Venexiana (conductor Davide Pozzi) in Lisbon. With this last ensemble she made her debut during the Schwetzinger SWR Festspiele as Speranza L'Orfeo and Ericlea Il ritorno d'Ulisse.
Sophia has also received several prizes at competitions, including second prize at the 21st National Singing Competition in Greece and the audience prize at the Prix d'Harmonie competition in Rotterdam (2010). As a versatile young singer, Sophia is praised for her 'rich and velvety low register'.